王东辉

王东辉

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职称: 副教授

教育背景:

2012.9-2017.7 中科院上海硅酸盐研究所 博士

2008.9-2012.6 四川大学 学士

工作履历:

2019.6-至今 可乐2主管 讲师/副教授

2017.8-2019.6 中科院上海硅酸盐研究所 助理研究员

学术兼职:

《无机材料学报》青年编委

《Frontiers in Chemistry》特刊编辑

《可乐2主管学报》青年编委

  中国生物材料学会会员

研究领域与承担项目:

研究领域:

医用金属材料表面改性

主要从事生物医用钛、镍钛、镁合金表面改性研究,着重研究植/介入材料所涉及的关键科学问题-抗癌能力和抗菌能力:

(1)医用金属材料表面改性与修饰

(2)抗腐蚀涂层构建

(3)抗菌、抗癌、生物活性薄膜/涂层

(4)材料对细胞、细菌行为的识别与调控

基金和项目:

(1)国家自然科学基金委员会,面上项目,52271245,电响应钛基假体表面设计及其监测与杀伤骨肉瘤机制研究,2023-01-2026-12,主持

(2)国家自然科学基金委员会,青年项目,51901239,钛表面微环境自响应载药薄膜构建及其选择性生物学效应研究,2019-01至2022-12,主持

(3)国家自然科学基金委员会,面上项目,52271244,锌合金表面载氯纳米膜的设计及诱导中性粒细胞免疫抗菌与骨再生机制,2023-01-2026-12,合作单位负责人

(4)天津市多元投入基金,青年项目,层状双氢氧化物薄膜修饰钛用于骨科植入物及其抗菌成骨性能研究,2021-10至2023-09,主持

(4)河北省自然科学基金,青年项目,E2021202001,镍钛表面热化疗一体化载药薄膜构建及其抗胆囊癌机制,2021-01至2023-12,主持

(5)上海市科学技术委员会,“扬帆计划”项目18YF1426900,微环境响应层状双氢氧化物薄膜构筑和性能研究,2018-05至2021-04,主持

(6)中科院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室,主任青年基金项目,SKL201706,镍钛表面智能响应薄膜构筑和性能研究,2018-01至2020-12

奖励与荣誉:

(1)入选“上海科技英才扬帆计划”

(2)可乐2主管“元光学者”

(3)中国生物材料学会医用金属材料分会学术年会“优秀青年学者”

学术成果:

(1)Biomedical implants with charge-transfer monitoring and regulating abilities,2021年,Advanced Science

(2)Tuning the surface potential to reprogram immune microenvironment for bone regeneration,2022年,Biomaterials

(3)Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film,2023,Bioactive Materials

(4)Layered double hydroxide-based micro “chemical factory” with arsenic processing and screening functions on nitinol for gallbladder cancer treatment,2022年,Small

(5)Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities,2022年,Materials Today Bio

(6)Metallic nanoparticle-doped oxide semiconductor film for bone tumor suppression and bone regeneration,2022年,ACS Applied Materials & Interfaces

(7)Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level,2021年,Materials Science & Engineering C

(8)Thermosensitive -hydrogel-coated titania nanotubes with controlled drug release and immunoregulatory characteristics for orthopedic applications,2021年Materials Science & Engineering C

(9)Enhanced bactericidal effect of calcinated Mg–Fe layered double hydroxide films driven by the fenton reaction,2023年,International Journal of Molecular Sciences

(10)NIR-triggered crystal phase transformation of NiTi-layered double hydroxides films for localized chemothermal tumor therapy,2018年,Advanced Science

  (11) 11 Peng F, Cheng S, Zhang RY, Li M, Zhou JL, Wang DH*, Zhang Y*, Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration. Regenerative Biomaterials, 2020. doi: 10.1093/rb/rbaa044

  (12) Wang DH, Li QW, Qiu JJ, Zhang XM, Liu XY*. Corrosion motivated ROS generation helps endow titanium with broad-spectrum antibacterial abilities. Advanced Materials Interfaces,2019, 1900514.

  (13) Wang DH, Peng F, Li JH, Qiao YQ, Li QW, Liu XY*. Butyrate inserted Ni-Ti layered double hydroxide film for H2O2 mediated tumor and bacteria killing. Materials Today, 2017, 20(5), 238-257.

  (14) Li BE, Zhang L, Wang DH*, Liu XY*, Li HP, Zhou LX, Liang CY, Zhao XY. Thermo-sensitive hydrogel on anodized titanium surface to regulate immune response, Surface & Coating Technology,2021,405.

  (15) Li BE, Ma JW, Wang DH*, Liu XY*, Li, HP; Zhou, LX; Liang, CY; Wang, HS. Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces [J]. Biomaterials Science, 2019, DOI:10.1039/c9bm00862d.

  (16) Wang DH, Ge NJ, Li JH, Qiao YQ, Zhu HQ, Liu XY*. Selective tumor cell inhibition effect of Ni-Ti layered double hydroxides thin films driven by the reversed pH gradients of tumor cells. ACS Applied Materials & Interfaces, 2015, 7(15): 7843-7854.